2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-128483R
    Fusaric acid (Standard) 536-69-6
    Fusaric acid (Standard) is the analytical standard of Fusaric acid (HY-128483). This product is intended for research and analytical applications. Fusaric acid is an orally active multi-pathway inhibitor with the activity of inducing oxidative stress and apoptosis. Fusaric acid can chelate divalent metal cations, damage mitochondrial membrane structure, and activate apoptosis-related proteases such as Caspase-3/7, -8, and -9. Fusaric acid also regulates Bax/Bcl-2 protein, inhibits fibrosis-related signaling pathways such as NF-κB, TGF-β1/SMADs, and PI3K/AKT/mTOR, and reduces collagen deposition. Fusaric acid is also a dopamine β-hydroxylase inhibitor, which reduces endogenous levels of norepinephrine and epinephrine in the brain, heart, spleen, and adrenal glands. Fusaric acid can play a role in myocardial fibrosis and improve cardiac hypertrophy in heart disease, and can also be used in the study of esophageal cancer and liver cancer.
    Fusaric acid (Standard)
  • HY-128544A
    Proroxan hydrochloride 33025-33-1 98%
    Proroxan hydrochloride is a non-selective adrenergic α-antagonist. Proroxan hydrochloride can be used in the study of hypertension.
    Proroxan hydrochloride
  • HY-128696R
    Amlodipine aspartic acid impurity (Standard) 400602-35-9
    Amlodipine aspartic acid impurity (Amlodipine aspartate) (Standard) is the analytical standard of amlodipine aspartic acid impurity. This product is intended for research and analytical applications. Amlodipine aspartic acid impurity is the impurity of Amlodipine aspartic acid. Amlodipine aspartic acid is a calcium channel blocker with antihypertensive and antianginal properties. Amlodipine aspartic acid impurity can control blood pressure. Amlodipine aspartic acid impurity corrects gut dysbiosis and enhances taurine and hypotaurine metabolism. Amlodipine aspartic acid impurity can be studied in research for NAFLD and hypertension.
    Amlodipine aspartic acid impurity (Standard)
  • HY-128741R
    D-Allose (Standard) 2595-97-3
    D-Allose (Standard) is the analytical standard of D-Allose (HY-128741). This product is intended for research and analytical applications. D-Allose exhibits antitumor activity against various cancer cells. D-Allose scavenges reactive oxygen species (ROS) and reduces oxidative stress damage. D-Allose exhibits anti-inflammatory and neuroprotective through inhibition of TLR4/PI3K/AKT signaling pathway. D-Allose exhibits antihypertensive, cryoprotective, and anti-osteoporotic activities.
    D-Allose (Standard)
  • HY-128850R
    N-Acetyl-D-mannosamine (Standard) 3615-17-6 98%
    N-Acetyl-D-mannosamine (Standard) is an analytical standard for N-Acetyl-D-mannosamine. This product is intended for research and analytical applications. N-Acetyl-D-mannosamine (ManNAc) is an orally active sialic acid (Sialic Acid) precursor that can prevent hypertension by increasing sialylation of IgG and has potential for use in cardiovascular disease research. N-Acetyl-D-mannosamine activates hypocretin (HCRT) gene expression and alters
    N-Acetyl-D-mannosamine (Standard)
  • HY-129029R
    Bisoprolol (Standard) 66722-44-9
    Bisoprolol (Standard) is the analytical standard of Bisoprolol. This product is intended for research and analytical applications. Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker with little activity on β2-receptor. Bisoprolol has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research.
    Bisoprolol (Standard)
  • HY-129047E
    Trypsin, porcine pancreas (Cell culture grade) 9002-07-7
    Trypsin, porcine pancreas (Cell culture grade) is a serine protease enzyme that hydrolyzes proteins at the carboxyl side of the Lysine or Arginine. Trypsin, porcine pancreas (Cell culture grade) has an excellent protein digestibility for α-lactalbumin and β-casein. Trypsin, porcine pancreas (Cell culture grade) activates kallikrein and regulates the blood pressure. Trypsin, Human Pancreas is an activator for PAR, thereby regulating cellular inflammatory and immune responses.
    Trypsin, porcine pancreas (Cell culture grade)
  • HY-129953A
    5-trans Prostaglandin F2α 36150-01-3 98%
    5-trans Prostaglandin F2α is an endogenous metabolite present in Blood that can be used for the research of Myocardial Infarction.
    5-trans Prostaglandin F2α
  • HY-129953C
    5-trans Prostaglandin F2α tromethamine 330796-56-0 98%
    5-trans Prostaglandin F2α tromethamine is a derivative of 5-trans Prostaglandin F2α (HY-129953A). 5-trans Prostaglandin F2α is an endogenous metabolite present in blood that can be used for the research of myocardial infarction.
    5-trans Prostaglandin F2α tromethamine
  • HY-130319A
    9-HEPE 286390-03-2 98%
    9-HEPE, a oxidation product of Eicosapentaenoic acid, is a racemic mixture of 9(R)-HEPE and 9(S)-HEPE. 9-HEPE induces fatty acid oxidation, adipogenesis, and glucose uptake via activation of PPARs in vivo.
    9-HEPE
  • HY-130353R
    Desethylamiodarone hydrochloride (Standard) 96027-74-6
    Desethylamiodarone (hydrochloride) (Standard) is the analytical standard of Desethylamiodarone (hydrochloride). This product is intended for research and analytical applications. Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is a major active metabolite of Amiodarone. Desethylamiodarone hydrochloride is formed by CYP3A isoenzymes. Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM.
    Desethylamiodarone hydrochloride (Standard)
  • HY-130353S
    Desethyl Amiodarone-d4 hydrochloride 1189960-80-2 98%
    Desethyl Amiodarone-d4 (hydrochloride) is the deuterium labeled Desethylamiodarone hydrochloride. Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is a major active metabolite of Amiodarone. Desethylamiodarone hydrochloride is formed by CYP3A isoenzymes. Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM.
    Desethyl Amiodarone-d4 hydrochloride
  • HY-130778R
    N,N'-Diacetylchitobiose (Standard) 35061-50-8
    N,N'-Diacetylchitobiose (Standard) is the analytical standard of N,N'-Diacetylchitobiose. This product is intended for research and analytical applications. N,N'-Diacetylchitobiose is a dimer of β(1,4) linked N-acetyl-D glucosamine. N,N'-Diacetylchitobiose is the hydrolysate of chitin and can be used as alternative carbon source by E. coli. N,N'-Diacetylchitobiose also reverses myocardial depression.
    N,N'-Diacetylchitobiose (Standard)
  • HY-131515R
    Tri-Salicylic acid (Standard) 85531-17-5
    Tri-Salicylic acid (Standard) is the analytical standard of Tri-Salicylic acid (HY-131515). This product is intended for research and analytical applications. Tri-Salicylic acid (Compound III) is a compound with similar properties to salicylic acid. Tri-Salicylic acid can be used in the research of inflammation, obesity, diabetes, and cardiovascular disease.
    Tri-Salicylic acid (Standard)
  • HY-131776A
    2-Chloro-ADP sodium 82927-78-4 98%
    2-Chloro-ADP (2-Chloroadenosine 5′-diphosphate) sodium is a Adenosine 5'-diphosphate (ADP; HY-W010918) derivative that induces human platelet aggregation and inhibits stimulated adenylate cyclase. 2-Chloro-ADP sodium inhibits mortalin nucleotide-binding domain (NBD) with a Ki of 45.05 μM.
    2-Chloro-ADP sodium
  • HY-134353A
    ADP-β-S trisodium 98%
    ADP-β-S (trisodium) is an ADP analog and partial agonist. ADP-β-S (trisodium) induces human platelet aggregation and inhibits PGE1-stimulated adenylate cyclase.
    ADP-β-S trisodium
  • HY-134454A
    Z-Pro-prolinal 88795-32-8 98%
    Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) is a specific, orally active prolyl endopeptidase (PREP) inhibitor with an IC50 of 0.4 nM for porcine PREP.
    Z-Pro-prolinal
  • HY-13463BS
    Avatrombopag-d8 hydrochloride 98%
    Avatrombopag-d8 (hydrochloride) is deuterium labeled Avatrombopag (hydrochloride). Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC50=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A.
    Avatrombopag-d8 hydrochloride
  • HY-135328S
    Norverapamil-d7 263175-44-6 98%
    Norverapamil-d7 is a deuterium labeled Norverapamil ((±)-Norverapamil). Norverapamil, an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.
    Norverapamil-d7
  • HY-135356R
    m-Nifedipine (Standard) 21881-77-6
    m-Nifedipine (Standard) is the analytical standard of m-Nifedipine. This product is intended for research and analytical applications. m-Nifedipine is an impurity of Nifedipine (BAY-a-1040). Nifedipine is a potent calcium channel blocker and agent of choice for cardiac insufficiencies.
    m-Nifedipine (Standard)
Cat. No. Product Name / Synonyms Application Reactivity